LESION AXONAL DIFUSA PDF

DAÑO AXONAL DIFUSO SECUNDARIO A TRAUMATISMO CRANEOENCEFÁLICO Neurología del paciente en situación critica ( Neurocríticos).

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Axoplasmic transport and neuronal responses to injury Archived at the Wayback Machine.

Diffuse axonal injury | Radiology Reference Article |

DAI can occur across the spectrum of traumatic brain injury TBI severity, wherein the burden of injury increases from mild to severe. As such, it is usually a safe assumption that if a couple of small hemorrhagic lesions are visible on CT, the degree of damage is much greater. Leion Journal of Emergency Medicine. Mechanism of calcium entry during axon injury and degeneration.

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You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Nerve injury Peripheral nerve injury classification Wallerian degeneration Injury of accessory nerve Brachial plexus injury Traumatic neuroma.

Over the first few days, the degree of surrounding edema will typically increase, although by 3-months post-injury FLAIR changes will have largely resolved 7. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors.

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Diffuse axonal injury

Mitochondriadendritesand parts of the cytoskeleton damaged in the injury have a limited ability to heal and regenerate, a process which occurs over 2 or more weeks. Intracranial hemorrhage Intra-axial Intraparenchymal hemorrhage Intraventricular hemorrhage Extra-axial Subdural hematoma Epidural hematoma Subarachnoid hemorrhage Brain herniation Cerebral contusion Cerebral laceration Concussion Post-concussion syndrome Second-impact syndrome Dementia pugilistica Chronic traumatic encephalopathy Diffuse axonal injury Abusive head trauma Penetrating head injury.

Figure 1 Figure 1.

Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels. The Journal of Neuroscience. Check for errors and try again.

Retrieved from ” https: Journal of Clinical Neuroscience. Central Nervous SystemTrauma. Misalignment of cytoskeletal elements after stretch injury can lead to tearing of the axon and death of the neuron. Archives of Clinical Neuropsychology. Retrieved 18 July While it was once thought that the main cause of axonal separation was tearing due to mechanical forces during the trauma, it is now understood that axons are not typically torn upon impact; rather, secondary biochemical cascadeswhich occur in response to the primary injury which occurs as the result of mechanical forces at the moment of trauma and take place hours to days after the initial injury, are largely responsible for the damage to axons.

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Actual complete tearing of the axons is only seen in severe cases. In the majority of cases, these forces result in damage to the cells and result in edema. Journal of Neurology, Neurosurgery, and Psychiatry. Case 8 Case 8.

Diffuse axonal injury – Wikipedia

This page was last edited on 4 Decemberat By using this site, you agree to the Terms of Use and Privacy Policy. Howard University College of Medicine. MRI is the modality of choice for assessing suspected diffuse axonal injury even in patients with entirely normal CT of the brain Retrieved December 14, Textbook Of Traumatic Brain Injury.

Non-hemorrhagic lesions are hypodense. In other projects Wikimedia Commons.

Log in Sign up. Traumatically induced axonal damage: Diffuse axonal injury Lesiob weighted image SWI of diffuse axonal injury in trauma at 1.

DAI is the result of traumatic shearing forces that occur when the head is rapidly accelerated or decelerated, as may occur in car accidents, falls, and assaults.

Unable to process the form. Case 1 Case 1.