Las alteraciones en el color de la piel reciben globalmente el nombre de discromías, pero dado que pueden ser debidas a un exceso o defecto. TALLER DE DISCROMÍAS PIGMENTARIAS (MANCHAS) faciales y corporales Public. · Hosted by Distribuidora Go Rosario. Interested. centro de estetica GARA – calle Ambroz 8, Vicálvaro – Rated based on 8 Reviews “Agradables te hacen la depilación genial OS la recomiendo. La.

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Ejemplo 5 example 5.

The results of the effects of time and produced having a value less than 0. Psycho-sensory subjective assessment of cosmetic acceptability in regard to the product and its conditions of use have been made thanks to some questions raised in a questionnaire administered to each volunteer the D60 questionnaire. It has made an assessment of the overall tolerance the D60 according to a severity scale of 4 levels. The melanic index was calculated using the following equation: There have been a standard photographs, right profile and left profile at each stage of study.

It may also be in solid form, for example in the form of a bar. The D60 has been carried out a questionnaire on the subject in relation to the cosmetic qualities of the product tested. The study of the functional signals at each side of the face, feelings of tension, itching, burning, does not show any significant variation. Surprisingly, we have now demonstrated that oxazolines also exhibit depigmenting action. Numerous synthetic routes are known for preparing oxazolines according to the invention.

Advantageously, said oxazoline is 2-undecyl-4,4-dimethyl-1,3-oxazoline, called OX, of formula: Indeed, NO is involved in regulating pigmentation. Peutz-Jeghers syndrome in a year-old boy: The amount of melanin present in the cells at the end of the incubation was measured by spectrophotometry. Compositions and method comprising heterocyclic compounds containing two heteroatoms. The composition according to the invention may also contain adjuvants that are common in the cosmetics field, such as stabilizers, preservatives, antioxidants, solvents, perfumes, chelating agents, odor absorbers, some chemical filters or minerals, a mineral pigments, surfactants, polymers, silicone oils and dyestuffs.


The co-cultures are incubated for hours in the presence or absence of the above compounds. The D60, has given an opinion on the effectiveness of the product used depigmentation using the following scale: The invention also relates to a method of cosmetic treatment for lightening the skin, characterized in that applied topically a composition comprising at least one oxazoline. Discromuas each treated side it has been measured level index pkgmentarias or similar areas exhibiting hyperpigmentation, to study the depigmenting effect of each product.

Lessons from the past–looking to the future. In the French patent application FR 2,, the inventors describe the use of oxazolines, allowing inhibition of migration of Langerhans cells.

There is therefore a need for compositions having depigmenting activity or skin lightening and which are well tolerated by the skin. The present invention relates to the use of a cosmetic composition having depigmenting action or lightening skin, comprising, as active principle, at least one oxazoline.

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After treatment, the cell sheets are washed. Ejemplo 1 Example 1. Melasma occurs most often in women using oral contraception or during pregnancy mask of pregnancy, chloasma. After 60 days, the dermatologist judged whether hyperpigmentation has been reduced from “satisfactory” or “very satisfactory” in Therefore, the invention relates to the use of at least one oxazoline, a depigmenting active principle, in a depigmenting composition.

Se ha verificado la homogeneidad de las varianzas y la normalidad de las distribuciones en todos los casos. Use according to any of the preceding claims, wherein the composition further comprises another depigmenting active principle.

The results of measurements at each measuring point on each subject and pigmenfarias been the subject of an average by area treated areas, areas of healthy skin. The composition used according to the invention may contain other active agents having depigmenting action, causing a complementary or synergistic effect. Pigmentariax diferencia entre las mediciones a T1 es de 13,84 unidades arbitrariasmientras que era de 20,29 a T0.

Cosmetic use of at least one oxazoline, a depigmenting active principle, in a depigmenting composition. Oxazolines can also be synthesized by the reaction of epoxides nitriles, by reaction of thionyl chloride on hydroxyamides or also by the action of an acid on a aziridinilfosfina. We have studied pigmetnarias cosmetic depigmenting efficacy and skin compatibility clinic cosmetic formulation according to the invention in the field of melasma of the face. Thus, these can be prepared by chemical synthesis by reacting a fatty acid or methyl ester and an amino-alcohol, most often in the presence of an azeotropic agent in order to favor the elimination of the water formed and the methanol formed.


According to an advantageous embodiment of the present invention, said oxazoline is an oxazoline of type 1 selected from the group consisting of 2-undecylhydroxymethylmethyl-1,3-oxazoline, 2-undecyl-44-dimethyl-1,3-oxazoline, E -4,4-dimethylheptadecenyl-1,3-oxazoline, 4-hydroxymethylmethylheptadecyl -1,3-oxazoline, E hydroxymethylmethylheptadecenyl-1,3-oxazoline, 2-undecylethylhydroxymethyl-1,3 oxazoline.

The following examples illustrate the present invention. Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent. Tyrosinase inhibition due to interaction of homocysteine with copper: Cosmetic use of at least one oxazoline, as an active ingredient despigmentante in a depigmentation composition. Depigmenting or lightening cosmetic composition comprising at least one oxazoline as active principle. Composition for applying to skin externally containing extract from seeds of ginseng.

Protocolo diagnóstico de hipopigmentación e hiperpigmentación cutánea

Cosmetic use according to any of the preceding claims, characterized in that said oxazoline is a type 1 oxazoline selected from the group consisting of 2-undecylhydroxymethylmethyl-1,3-oxazoline, 2 -undecil-4,4-dimethyl-1,3-oxazoline, E -4,4-dimethylheptadecenyl-1,3-oxazoline, 4-hydroxymethylmethyl heptadecyl-1,3-oxazoline, E hydroxymethylmethylheptadecenyl-1,3-oxazoline and 2-undecylethyl hydroxymethyl-1,3-oxazoline. Cosmetic treatment process for skin lightening, characterized in that applied topically a composition comprising at least one oxazoline.

The calculation used has been simplified MASI, ie: This melanin is produced by the melanocytes in the basal layer, under the action of tyrosinase, copper and oxygen. They act on the formation, transport, the color of melanin itself or on the viability of melanocytes melanocitotoxicidad. Each treatment condition was performed in triplicate.

El color de la piel se debe a varias sustancias: The average results pigmentraias for the hyperpigmented treated areas are: Pitiriasis alba Dartros 2.