The pathophysiology of anemia and the basis of its clinical investigation. Pruebas que evalúan el estado del hierro: Hierro del compartimiento funcional: Ferremia: Capacidad total de saturación de hierro (CTSH). Transcript of Clasificacion de anemias. Disminución de la capacidad transportadora de oxigeno de la sangre. Adaptaciones fisiológicas.

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The advantages are clear if the cause is a cancer that can be diagnosed at an early stage.

It is as if the body were trying to make up in clasuficacion quantity what it lacks in quality. Generally, anemia must be fairly severe hemoglobin IV.

Iolascon A, Perrota S. However, in daily clinical practice, it is more useful to start with the analytical parameters of the hemogram.

Clinical signs of a slowly developed anemia are pallor, tachycardia, and a systolic ejection murmur. Evaluation of microcytic anemia.

In pernicious anemia, pepsinogen I levels are low, gastric pH is high and gastric acid secretion does not respond to stimulation with histamine or pentagastrin. Conversely, anemias developing over periods long enough to allow compensatory mechanisms to operate will clasiticacion much greater loss of rbc mass before producing symptoms. In both cases, there is a typical increase in reticulocytes.

Clasificacion de anemias by Carolina Isabel Guifarro Salgado on Prezi

However, the absolute reticulocyte enumeration per mm 3 overestimates the actual activity of erythropoiesis, since reticulocytes are released earlier and remain longer in the circulating blood. Iron deficiency is the most common cause of anemia, so the first step in diagnosis should be directed toward confirmation or exclusion of IDA. Red cell extrinsic causes: It is important to note that microcytosis without anemia is characteristic of thalassemia trait, but also of polycythemia associated with iron deficiency[ 27 ].


Other parameters of iron metabolism serum iron, total transport capacity of iron, and transferrin are unable to distinguish with certainty IDA from ACD[ 23 ]. The distribution of nutrient-deficiency anemia in the elderly is: Although by definition total body red cell mass is decreased in anemia, in the chronically anemic patient the total blood volume paradoxically is increased, due to increased plasma volume.

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Redistribution of blood flow In anemia selective vasoconstriction of blood vessels subserving certain nonvital areas allows more blood to flow into critical areas. This is caused by alteration of bone marrow progenitor cells, which can be located at different stages of differentiation and maturation.

Pathogenic mechanisms involved in the production of anemia clasificwcion very simple: Subictericia de escleras por hematopoyesis ineficaz y hemolisis.

Physiologic compensation for decreased rbc mass Each physiologic mechanism will be discussed below. Support Center Support Center.

Keep in mind that if anemia develops through rapid enough bleeding, the hematocrit and hemoglobin will be normal since in hemorrhage the rbc’s and plasma are lost in proportion.

Thymoma is the most common cause of acquired pure red cell aplasia.

Classification of anemia for gastroenterologists

In men and postmenopausal women, the bigger concern should be to rule out the presence of occult bleeding. The association with pathological concomitant processes, elevation of erythrocyte sedimentation rate ESR and the absence of morphological alterations in peripheral blood smears supports the suspicion of ACD[ 40 ].


These clsaificacion the hyporegenerative anemias. The reticulocyte count is useful to distinguish anemia in clasificacioj there is an appropriate bone marrow response from that in which there is a decrease in the production of erythrocytes.

Classification of anemia for gastroenterologists

ACD is the most prevalent form of clasificaacion after IDA in the general population[ 4068 ], but is even more common in hospitalized patients, regardless of sex and age[ 42676970 ].

The next step is the calculation of reticulocyte production index RPI: Causes that are intrinsic to hematopoietic stem cells: Recent developments in the anemia of chronic disease.

Zuckerman G, Benitez J.

El test de Schilling consta de dos partes. Tumor necrosis factor alpha, its soluble receptor I, and gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: Both parameters can be supplied routinely by most of the automatic hematological cell counters.

Nutritional Anemias and Anemia of Chronic Disease 4. Bowel resection, bacterial overgrowth Occult gastrointestinal blood loss Frequent: Celiac disease, gastrectomy, H pylori colonization. Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. Existen tres tipos de trascobalaminas: