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Pilot trial and follow-up. Twenty-one children and adolescents 17 boys and 4 girls with vvaran mean SD age of Antipsychotic drugs are prescribed for as many as half of pediatric psychiatric inpatients and one third of pediatric psychiatric outpatients.

The mean SD dosage of risperidone at the end of week 8 was 1.

Risperidone in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study

Most importantly, this was an open-label trial without a placebo-control group. All patients underwent a complete review of current health status, which included a careful medical history. Patients found to have extrapyramidal symptoms were to be treated with benztropine.

Rating scale to assess depression in school aged children. Risperidone for young children with mood disorders and aggressive behavior.

However, the beneficial effects of risperidone on inattention must be regarded as a tentative hypothesis until additional controlled studies have shown that risperidone is effective in improving inattention in children and adolescents with CD. The mean SD full-scale IQ for the group was Recruitment and screening procedures were designed to collect a carefully diagnosed sample of children and adolescents with severe CD. Statistical Analysis Data are reported as mean SD.

The convergent validity of the scale was demonstrated by the relationship between the Turkish form of the ISMI and various criteria scales.


No evidence of marked sedation, extrapyramidal symptoms, abnormalities in liver function, or significant changes on electrocardiography or complete blood count was found in our study. Vaan blood cell counts, liver function tests, and electrocardiograms were performed at baseline and at the end of the study.

Conduct disorder CD is one of the most common psychiatric disorders in childhood and adolescence. Long-term outcome of disruptive disorders. Although all patients exhibited mild sedation in the beginning of the study, this azmj event was transitory. Because only severe cases of CD were included in the study, our patients’ scores could improve more. Further studies, particularly with a double-blind, placebo-controlled design and larger samples, azki needed to better define the clinical use of risperidone in children and adolescents with CD.

The results of our study should be interpreted cautiously because of several limitations.

Assoc. Prof. Azmi Varan | Executive Education

The mean SD dosage of risperidone at the end of 8 weeks of treatment was 1. Support Center Support Center. Also, a significant improvement was found in the ratings of severity of illness after 8 weeks of treatment on the CGI severity of illness subscale.

The mean SD body weight gain of 1. No other psychotropic drugs were administered during the trial.

Risperidone was well tolerated in our study, and no patient was discontinued from the study because of adverse events. Pediatr Clin North Am. J Child Adolesc Psychopharmacol. The children who were diagnosed with CD in the same way by both investigators were included in the study. Antipsychotic medications for children and adolescents. The patients were treated with risperidone in an open-label fashion for 8 weeks, starting at a daily dosage of 0.


Matched-pair t test for CGI global improvement subscale was conducted between the end of week 4 and the end of treatment. The medication was individually regulated, with incremental increases up to 0. A double-blind pilot study of risperidone in the treatment of conduct disorder. This article has been cited by other articles in PMC. Risperidone in children and adolescents with pervasive developmental disorder: Twenty-one patients were screened for the study.

Similar to the findings of previous studies 5,7,8 in which risperidone was used in low doses, the only important adverse event in our study was body weight gain. Either your web browser doesn’t support Javascript or it is currently turned off. It has properties of potent 5-hydroxytryptamine 2 and dopamine 2 receptor antagonists. Gene Ontology GO Terms. These symptoms are often accompanied by hyperactivity, impulsive behavior, explosiveness, cognitive and learning problems, and poor social skills.

The lower levels of body weight gain in our study may have been the result of investigators warning parents about this side effect. All 21 patients were classified as having severe CD: Results of previous short-term studies 6,12 with low-dose risperidone also suggested that risperidone is well tolerated in children and adolescents, which is consistent with our findings.

Data are reported as mean SD. Practice parameters for the assessment and treatment of children and adolescents with conduct disorder.